Monica is a chef, and, as with most areas of her life, she is obsessive and competitive about it. Originally, she merely worked as a poorly paid chef at a restaurant called Iridium. After accepting a promotion, she was fired for accepting a gift from a food distributor. Monica remains unemployeed for a while before getting offered a job at a 50's theme restaurant called the Moondance Diner. At this time, Monica reveals that she worked at the famous Cafe des Artistes when she said "I was a sous-chef at Cafe des Artistes. How can I take a job where I have to make something called Laverne and Curly fries?" At the Moondance Diner, Monica wears a blonde wig, rollerskates and massive fake breasts (the same diner set was used in the first Spider-Man movie, in which Mary Jane was a waitress). While working at the diner, she met millionaire Pete Becker who used his money to open a restaurant and appoint Monica as head chef. After the relationship failed due to the consequences of Pete's desire to become the "Ultimate Fighting Champion," Monica began a short-lived catering business with Phoebe.

Monica was eventually hired as head chef at a local restaurant, Allesandro's, putting an end to the catering business. At first, her employees disliked Monica due to the fact that three of them were the children of the previous head chef, coupled with a fairly vicious review she had published in a local newspaper about the restaurant. However, Monica hired her friend Joey as a waiter, solely to fire him, thereby appearing to be a tough boss. It apparently worked, as her problems with her employees were reduced. She left Alessandro's when Chandler's firm required him to relocate to Tulsa, Oklahoma; however, when she contacted a job-hunter about Tulsa restaurant openings, she found out about, and accepted, her new job as head chef at Javu, an upmarket restaurant.