Chandler worked as an IT Procurement Manager with the forementioned specialization; a job which he thoroughly loathed. It remains a running joke through most of the seasons that no one quite knows what he does. His friends, in a trivia game, could not guess his job in one instance, with Rachel hysterically calling him a "transponster." Joey once said "Jeez, Chandler, you call yourself an accountant?", to which Chandler incredulously replied, "No!" Everyone else would go on to admit that they had no idea what he really did for a living. Monica admits several times that she doesn't pay attention when he talks about his work, but finally learns what he does when he quits in season 9—she calls it Statistical Analysis And Data Reconfiguration ("I quit and you learn what I do?!") (but he does mention his job title in "The One With The Cooking Class," season 8), a job which inspired Chandler's oft-referenced office slang word "WENUS" (Weekly Estimated Net Usage Statistics), as well as the "ANUS" (Annual Net Usage Statistics).

However, Chandler was unable to simply quit his job as it was his nature to avoid ending anything forcefully, be it his job, a relationship, or even his membership with a gym. Chandler tried to quit his job in season 1, but was lured back by a huge raise and a yearly bonus structure. Eventually he does finally quit after accidentally agreeing to work in Tulsa, Oklahoma. After this, he takes a job in the advertising business.

In an alternate reality storyline during the show ("The One That Could Have Been"), Chandler did have the guts to quit his job and worked as a freelance writer, specializing in comics.